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Fatty Acid

Safflower Oil

Also known as: Carthamus tinctorius oil, Safflower seed oil, High-linoleic safflower oil, Conjugated linoleic acid source

C
Evidence

Safflower oil is a plant-based oil rich in polyunsaturated fatty acids, commonly used as a carrier for conjugated linoleic acid (CLA) in supplement formulations. Evidence for independent health benefits beyond its fatty acid content remains limited.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • CLA supplement carrier
  • Source of linoleic acid
  • Fatty acid supplementation

How it works

  • Provides omega-6 polyunsaturated fatty acids (primarily linoleic acid)
  • Used as delivery vehicle for fat-soluble compounds like CLA

Dosage

Typical range
1,000–3,000 mg daily (as part of CLA or multi-ingredient formulas)
Timing
With meals
With food
Recommended; fat-soluble and better absorbed with dietary fat
Duration
Can be used long-term; no established maximum duration
Special populations
Generally safe in pregnancy and lactation in typical dietary amounts; those with seed allergies should use caution

Forms

  • Softgel· 70/100
  • Liquid oil· 70/100
  • Capsule· 70/100

Safety

Common side effects

  • Mild gastrointestinal upset (when used in high doses)
  • Nausea

Contraindications

  • Safflower allergy or sensitivity
  • History of allergic reaction to Asteraceae family plants

Evidence notes

Safflower oil itself has limited independent research. Some studies suggest modest effects on inflammation or lipid metabolism, but evidence is preliminary and inconsistent. Grade reflects that it is primarily used as a carrier oil rather than an active ingredient with established benefits.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.