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Antioxidant

S-Acetyl L-Glutathione

Also known as: SAC, SAGL, acetylated glutathione, N-acetyl L-glutathione

C
Evidence

S-Acetyl L-Glutathione is a stabilized form of the tripeptide glutathione designed to improve bioavailability and reduce oxidative stress. Limited human clinical evidence supports efficacy, though animal and in vitro studies suggest potential cellular protective effects.

Primary uses

  • Antioxidant support
  • Cellular detoxification
  • Oxidative stress reduction
  • Liver support

How it works

  • Direct free radical scavenging
  • Support for glutathione peroxidase and other antioxidant enzymes
  • Conjugation and elimination of toxins
  • Improved oral bioavailability compared to unacetylated glutathione

Dosage

Typical range
200-500 mg daily
Timing
With or without food; typically once or twice daily
With food
Can be taken with or without food; may improve absorption with a light meal
Duration
Long-term safety data in humans is limited; typical use spans weeks to months
Special populations
Safety in pregnancy, nursing, and children not well-established; consult healthcare provider

Forms

  • Capsule· 70/100
  • Powder· 70/100

Safety

Common side effects

  • Generally well-tolerated
  • Occasional mild gastrointestinal upset
  • Rare headache or dizziness

Contraindications

  • Hypersensitivity to glutathione or acetylated compounds
  • Caution in individuals on immunosuppressive therapy (glutathione may enhance immune function)

Evidence notes

Acetylation improves stability and absorption compared to standard glutathione, but human clinical trials directly measuring physiological outcomes remain limited. Most evidence comes from in vitro and animal studies. Bioavailability claims are promising but not definitively established in humans.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.