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Antioxidant

R-Alpha Lipoic Acid

Also known as: R-ALA, R-alpha-lipoic acid, right-handed alpha-lipoic acid, RLA

B
Evidence

R-alpha lipoic acid is the biologically active S-enantiomer of alpha-lipoic acid, a mitochondrial cofactor with antioxidant and metabolic effects. It has stronger evidence for neuropathic pain and metabolic health compared to the racemic mixture, though human data remains limited.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Neuropathic pain support
  • Blood sugar metabolism
  • Antioxidant support
  • Mitochondrial function
  • Nerve health

How it works

  • Mitochondrial electron transport cofactor
  • Free radical scavenging
  • Recycling of vitamins C and E
  • AMPK activation
  • Glucose transporter upregulation

Dosage

Typical range
300-600 mg daily
Timing
With or without food; divided doses may improve absorption
With food
Can take with or without food, though food may slow absorption slightly
Duration
Typically requires 4-12 weeks of consistent use for neuropathy effects; can be used long-term
Special populations
Diabetic individuals should monitor blood glucose; may enhance insulin sensitivity

Forms

  • Powder· 70/100
  • Capsules· 70/100
  • Tablets· 70/100
  • Sodium R-lipoate (stabilized form)· 70/100

Safety

Common side effects

  • Mild nausea or GI upset
  • Rash (rare)
  • Hypoglycemia risk in diabetics on medications

Contraindications

  • Thiamine (B1) deficiency risk with very high doses
  • Use cautiously in hypoglycemia-prone individuals
  • Caution in those with biotin deficiency

Evidence notes

Strong mechanistic rationale and good clinical evidence for diabetic neuropathy (especially IV formulations) and metabolic markers. R-enantiomer shows superior bioavailability and activity versus racemic ALA. Oral data less robust than IV but still supportive.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.