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Antioxidant

R-Alpha Lipoic Acid

Also known as: R-ALA, R-alpha-lipoic acid, right-handed alpha-lipoic acid, RLA

B
Evidence

R-alpha lipoic acid is the biologically active S-enantiomer of alpha-lipoic acid, a mitochondrial cofactor with antioxidant and metabolic effects. It has stronger evidence for neuropathic pain and metabolic health compared to the racemic mixture, though human data remains limited.

Primary uses

  • Neuropathic pain support
  • Blood sugar metabolism
  • Antioxidant support
  • Mitochondrial function
  • Nerve health

How it works

  • Mitochondrial electron transport cofactor
  • Free radical scavenging
  • Recycling of vitamins C and E
  • AMPK activation
  • Glucose transporter upregulation

Dosage

Typical range
300-600 mg daily
Timing
With or without food; divided doses may improve absorption
With food
Can take with or without food, though food may slow absorption slightly
Duration
Typically requires 4-12 weeks of consistent use for neuropathy effects; can be used long-term
Special populations
Diabetic individuals should monitor blood glucose; may enhance insulin sensitivity

Forms

  • Powder· 70/100
  • Capsules· 70/100
  • Tablets· 70/100
  • Sodium R-lipoate (stabilized form)· 70/100

Safety

Common side effects

  • Mild nausea or GI upset
  • Rash (rare)
  • Hypoglycemia risk in diabetics on medications

Contraindications

  • Thiamine (B1) deficiency risk with very high doses
  • Use cautiously in hypoglycemia-prone individuals
  • Caution in those with biotin deficiency

Evidence notes

Strong mechanistic rationale and good clinical evidence for diabetic neuropathy (especially IV formulations) and metabolic markers. R-enantiomer shows superior bioavailability and activity versus racemic ALA. Oral data less robust than IV but still supportive.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.