Bioavailability Enhancer

Piperine (Black Pepper Extract)

Also known as: Black Pepper Extract, Black Pepper Fruit Extract, BioPerine, Piper nigrum

Evidence

Alkaloid from black pepper that significantly enhances absorption of many nutrients and supplements by inhibiting drug-metabolizing enzymes and increasing intestinal permeability.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

Nutrient absorption enhancement
Curcumin bioavailability
Thermogenesis
Digestive support

How it works

Inhibits CYP3A4 and P-glycoprotein efflux transporters
Increases intestinal permeability temporarily
Inhibits glucuronidation in liver and intestine
Enhances thermogenesis via TRPV1 activation

Dosage

Typical range: 5-20 mg daily
Timing: With target supplements/meals
With food: Yes, take with supplements to enhance
Duration: Safe for long-term use at recommended doses
Special populations: Caution with narrow therapeutic index drugs

Forms

BioPerine (standardized 95%)
Generic piperine extract
Black pepper fruit extract

Safety

Common side effects

GI irritation at high doses (rare)

Contraindications

Concurrent use with drugs having narrow therapeutic index without medical supervision

Products containing Piperine (Black Pepper Extract)

Top-scoring supplements in our catalog that list Piperine (Black Pepper Extract) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Evidence notes

Strong evidence for bioavailability enhancement of curcumin (2000%+), CoQ10, resveratrol, and many other compounds

Grade A: Multiple well-designed human trials support the main claims.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.