Bioavailability Enhancer
Piperine (Black Pepper Extract)
Also known as: Black Pepper Extract, Black Pepper Fruit Extract, BioPerine, Piper nigrum
Alkaloid from black pepper that significantly enhances absorption of many nutrients and supplements by inhibiting drug-metabolizing enzymes and increasing intestinal permeability.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Piperine (Black Pepper Extract) product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Nutricost KSM-66 Capsules | 96 A | $0.28 |
| 2 | Doctor's Best High Absorption CoQ10 with BioPerine, 300 mg, 90 Veggie Softgels | 95 A | $0.41 |
| 3 | Doctor's Best High Absorption CoQ10 with BioPerine, 100 mg, 60 Veggie Caps | 95 A | $0.22 |
| 4 | Nutricost DIM Capsules | 94 A | $0.17 |
| 5 | Nutricost L-Tryptophan Capsules | 94 A | $0.15 |
| 6 | NOW Foods Magnesium Glycinate with BioPerine | 93 A | $0.22 |
| 7 | Transparent Labs Fat Burner | 92 A | $0.92 |
| 8 | Pure Encapsulations Curcumin 500 with Bioperine | 92 A | $0.85 |
| 9 | Transparent Labs BULK Pre-Workout | 90 A | $1.67 |
| 10 | Nutricost Turmeric Capsules | 90 A | $0.42 |
| 11 | NutraBio Curcumin Advanced | 90 A | $1.23 |
| 12 | Nutricost Pre-Workout For Women Powder | 89 A | $0.73 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Piperine (Black Pepper Extract) should I take?
The typical range is 5-20 mg daily. Safe for long-term use at recommended doses
When should I take Piperine (Black Pepper Extract)?
With target supplements/meals. Yes, take with supplements to enhance.
Which form of Piperine (Black Pepper Extract) is best?
BioPerine (standardized 95%) — Gold standard patented form. Other forms in the catalog: Generic piperine extract, Black pepper fruit extract.
Is Piperine (Black Pepper Extract) safe?
Commonly reported: GI irritation at high doses (rare). Serious warnings: May increase drug absorption - consult doctor if on medications. May affect drug metabolism - caution with hepatically cleared medications
Which Piperine (Black Pepper Extract) supplement scores highest?
Nutricost KSM-66 Capsules, at 96/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Nutrient absorption enhancement
- Curcumin bioavailability
- Thermogenesis
- Digestive support
How it works
- Inhibits CYP3A4 and P-glycoprotein efflux transporters
- Increases intestinal permeability temporarily
- Inhibits glucuronidation in liver and intestine
- Enhances thermogenesis via TRPV1 activation
Dosage
- Typical range
- 5-20 mg daily
- Timing
- With target supplements/meals
- With food
- Yes, take with supplements to enhance
- Duration
- Safe for long-term use at recommended doses
- Special populations
- Caution with narrow therapeutic index drugs
Forms
- BioPerine (standardized 95%)
- Generic piperine extract
- Black pepper fruit extract
Safety
Common side effects
- GI irritation at high doses (rare)
Contraindications
- Concurrent use with drugs having narrow therapeutic index without medical supervision
Products containing Piperine (Black Pepper Extract)
Top-scoring supplements in our catalog that list Piperine (Black Pepper Extract) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Strong evidence for bioavailability enhancement of curcumin (2000%+), CoQ10, resveratrol, and many other compounds
Grade A: Multiple well-designed human trials support the main claims.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.