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Amino Acid

N-Acetyl L-Glutamine

Also known as: N-Acetyl Glutamine, NAG, NAGL, Acetyl-L-Glutamine

D
Evidence

N-Acetyl L-Glutamine is an acetylated form of the amino acid glutamine that may support intestinal barrier function and immune health. Evidence for human supplementation is limited and primarily preliminary.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Intestinal barrier support
  • Gut health
  • Immune function
  • Post-exercise recovery

How it works

  • Provides acetylated glutamine for intestinal epithelial cell metabolism
  • May support tight junction integrity in the gut barrier
  • Potential glutamine precursor for immune cell function

Dosage

Typical range
2-5 grams daily
Timing
Can be taken any time; some suggest post-workout or between meals
With food
Can be taken with or without food
Duration
Optimal duration for supplementation is not well established
Special populations
Safety in pregnant/nursing women and children not well studied

Forms

  • Powder· 70/100
  • Capsule· 70/100

Safety

Common side effects

  • Generally well-tolerated
  • Mild gastrointestinal upset reported occasionally
  • Nausea possible at higher doses

Contraindications

  • Not recommended for those with glutamine sensitivity
  • Caution in severe liver or kidney disease

Evidence notes

Most human evidence is anecdotal or derived from animal studies. Very few robust RCTs in humans specifically examining N-Acetyl L-Glutamine supplementation. Glutamine itself has better evidence, but the acetylated form lacks sufficient clinical validation.

Grade D: Primarily pre-clinical or anecdotal; human efficacy not established.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.