Mineral
Magnesium (as Dimagnesium Malate)
Also known as: dimagnesium malate, magnesium malate
Magnesium is an essential cofactor in over 300 enzymatic reactions, supporting energy production, muscle relaxation, and nervous system function. Dimagnesium malate combines magnesium with malic acid, a compound involved in cellular energy metabolism.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Daily target & upper limit
420 mg / day · UL 350 mgMagnesium (as Dimagnesium Malate) has an established daily reference intake. See best forms, label synonyms, upper-limit warnings, and top-scoring supplements:
Magnesium (as Dimagnesium Malate) dosage reference →Primary uses
- muscle relaxation
- energy production
- nervous system support
- cardiovascular health
- bone health
How it works
- cofactor for ATP synthesis
- regulates calcium channels and muscle contraction
- supports neurotransmitter synthesis
- involved in protein synthesis
Dosage
- Typical range
- 300-420 mg daily (elemental magnesium)
- Timing
- divided doses, evening dose may support sleep
- With food
- can be taken with or without food
- Duration
- ongoing for general health
- Special populations
- kidney disease patients should consult provider; may help with pregnancy-related leg cramps
Forms
- dimagnesium malate· 70/100
Safety
Common side effects
- diarrhea or loose stools (dose-dependent)
- nausea
- abdominal cramping
Contraindications
- severe kidney disease
- myasthenia gravis
Products containing Magnesium (as Dimagnesium Malate)
Top-scoring supplements in our catalog that list Magnesium (as Dimagnesium Malate) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Magnesium has strong evidence for muscle function, migraine prevention, and cardiovascular support. The malate form is theoretical but plausible for energy-related applications.
Grade A: Multiple well-designed human trials support the main claims.
Related in Mineral
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.