Mineral
Magnesium (as Dimagnesium Malate)
Also known as: dimagnesium malate, magnesium malate
Magnesium is an essential cofactor in over 300 enzymatic reactions, supporting energy production, muscle relaxation, and nervous system function. Dimagnesium malate combines magnesium with malic acid, a compound involved in cellular energy metabolism.
Primary uses
- muscle relaxation
- energy production
- nervous system support
- cardiovascular health
- bone health
How it works
- cofactor for ATP synthesis
- regulates calcium channels and muscle contraction
- supports neurotransmitter synthesis
- involved in protein synthesis
Dosage
- Typical range
- 300-420 mg daily (elemental magnesium)
- Timing
- divided doses, evening dose may support sleep
- With food
- can be taken with or without food
- Duration
- ongoing for general health
- Special populations
- kidney disease patients should consult provider; may help with pregnancy-related leg cramps
Forms
- dimagnesium malate· 70/100
Safety
Common side effects
- diarrhea or loose stools (dose-dependent)
- nausea
- abdominal cramping
Contraindications
- severe kidney disease
- myasthenia gravis
Evidence notes
Magnesium has strong evidence for muscle function, migraine prevention, and cardiovascular support. The malate form is theoretical but plausible for energy-related applications.
Grade A: Multiple well-designed human trials support the main claims.
Related in Mineral
Check a full stack
Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.
Open the checkerMedical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.