Herbal Extract
Lentinula edodes Extract (Fruiting Body)
Also known as: Shiitake Mushroom Extract, Shiitake, Lentinula edodes, Black Forest Mushroom Extract
Shiitake mushroom fruiting body extract contains bioactive compounds including polysaccharides (beta-glucans), lentinan, and ergothioneine with immunomodulatory and antioxidant properties. Limited human clinical evidence supports immune function and general wellness support, though most research remains preliminary or conducted in vitro.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Immune system support
- General wellness and antioxidant support
- Cardiovascular health support
How it works
- Beta-glucan and lentinan immune activation via pattern recognition receptors
- Antioxidant activity from ergothioneine and phenolic compounds
- Modulation of inflammatory cytokines
Dosage
- Typical range
- 500–2000 mg daily (fruiting body extract equivalent)
- Timing
- Can be taken with or without meals; typically once or twice daily
- With food
- No specific requirement; food may improve absorption of fat-soluble compounds
- Duration
- May require 4–8 weeks of consistent use for perceived immune or wellness benefits; long-term use is considered safe
- Special populations
- Pregnancy/nursing: limited safety data; individuals with mushroom allergies should avoid; those on immunosuppressant therapy should consult a healthcare provider due to immune-stimulating properties
Forms
- Capsule· 70/100
- Powder· 70/100
- Extract (liquid or concentrated)· 70/100
- Dried fruiting body· 70/100
Safety
Common side effects
- Gastrointestinal upset (rare)
- Allergic reactions in mushroom-sensitive individuals (rare)
- Photosensitivity (lentinan-associated, very rare at supplemental doses)
Contraindications
- Mushroom allergy or hypersensitivity
- Active hematologic malignancies (theoretical; medical supervision recommended)
- Concurrent immunosuppressant therapy (potential interaction; consult healthcare provider)
Products containing Lentinula edodes Extract (Fruiting Body)
Top-scoring supplements in our catalog that list Lentinula edodes Extract (Fruiting Body) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
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Evidence notes
Shiitake contains well-characterized bioactive compounds with established in vitro and animal model activity. However, human clinical trial evidence is limited and often involves small sample sizes or combination products, making it difficult to isolate efficacy. Immunological mechanisms are plausible but require more rigorous RCT validation.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.