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Herbal Extract

Lentinula edodes Extract (Fruiting Body)

Also known as: Shiitake Mushroom Extract, Shiitake, Lentinula edodes, Black Forest Mushroom Extract

C
Evidence

Shiitake mushroom fruiting body extract contains bioactive compounds including polysaccharides (beta-glucans), lentinan, and ergothioneine with immunomodulatory and antioxidant properties. Limited human clinical evidence supports immune function and general wellness support, though most research remains preliminary or conducted in vitro.

Primary uses

  • Immune system support
  • General wellness and antioxidant support
  • Cardiovascular health support

How it works

  • Beta-glucan and lentinan immune activation via pattern recognition receptors
  • Antioxidant activity from ergothioneine and phenolic compounds
  • Modulation of inflammatory cytokines

Dosage

Typical range
500–2000 mg daily (fruiting body extract equivalent)
Timing
Can be taken with or without meals; typically once or twice daily
With food
No specific requirement; food may improve absorption of fat-soluble compounds
Duration
May require 4–8 weeks of consistent use for perceived immune or wellness benefits; long-term use is considered safe
Special populations
Pregnancy/nursing: limited safety data; individuals with mushroom allergies should avoid; those on immunosuppressant therapy should consult a healthcare provider due to immune-stimulating properties

Forms

  • Capsule· 70/100
  • Powder· 70/100
  • Extract (liquid or concentrated)· 70/100
  • Dried fruiting body· 70/100

Safety

Common side effects

  • Gastrointestinal upset (rare)
  • Allergic reactions in mushroom-sensitive individuals (rare)
  • Photosensitivity (lentinan-associated, very rare at supplemental doses)

Contraindications

  • Mushroom allergy or hypersensitivity
  • Active hematologic malignancies (theoretical; medical supervision recommended)
  • Concurrent immunosuppressant therapy (potential interaction; consult healthcare provider)

Evidence notes

Shiitake contains well-characterized bioactive compounds with established in vitro and animal model activity. However, human clinical trial evidence is limited and often involves small sample sizes or combination products, making it difficult to isolate efficacy. Immunological mechanisms are plausible but require more rigorous RCT validation.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.