Amino Acid
L-Serine
Also known as: Serine, L-2-amino-3-hydroxypropanoic acid, Ser
L-serine is a non-essential amino acid that serves as a precursor for phosphatidylserine and neurotransmitter synthesis. Limited clinical evidence supports its use for cognitive or neurological support, with most research occurring in specialized medical contexts.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Cognitive support
- Neurological function
- Phospholipid synthesis
- General amino acid nutrition
How it works
- Precursor for phosphatidylserine (PS) and sphingolipid synthesis
- Substrate for neurotransmitter production
- Component of protein synthesis
Dosage
- Typical range
- 1-5 g daily
- Timing
- Any time of day; can be taken with meals
- With food
- No specific requirement; food does not significantly impair absorption
- Duration
- Safe for long-term use as an amino acid
- Special populations
- Generally recognized as safe; minimal data in pregnancy/lactation
Forms
- Powder· 70/100
- Capsule· 70/100
Safety
Common side effects
- Generally well-tolerated
- Mild gastrointestinal upset possible at high doses
Contraindications
- None well-established; caution in severe renal impairment
Evidence notes
L-serine is a well-characterized amino acid with established biochemical roles, but clinical evidence for supplementation benefits in healthy populations is limited and preliminary. Most human studies involve specialized populations (e.g., neurological disorders) rather than general wellness.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.