Amino Acid
L-Ornithine L-Aspartate
Also known as: LOLA, ornithine aspartate, L-ornithine-L-aspartate salt
L-Ornithine L-Aspartate is a combined amino acid supplement studied primarily for its potential role in ammonia metabolism and liver health support. Evidence exists mainly in clinical settings for hepatic encephalopathy management, with limited data in healthy populations.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Ammonia metabolism support
- Liver health
- Athletic recovery (limited evidence)
- Hepatic encephalopathy management (clinical use)
How it works
- Substrate for hepatic urea cycle enzymes to increase ammonia clearance
- Supports nitrogen metabolism through ornithine and aspartate donation
- May enhance muscle protein synthesis
Dosage
- Typical range
- 2-3 grams daily, divided into 2-3 doses
- Timing
- With meals for better tolerance
- With food
- Recommended to reduce potential gastrointestinal discomfort
- Duration
- Clinical studies typically span 4-12 weeks; optimal duration for healthy populations unclear
- Special populations
- Not recommended for children without medical supervision; consult healthcare provider if pregnant or nursing
Forms
- Powder· 70/100
- Capsule· 70/100
- Tablet· 70/100
Safety
Common side effects
- Nausea
- Gastrointestinal upset
- Diarrhea (mild, dose-dependent)
Contraindications
- Severe renal impairment
- Known hypersensitivity to ornithine or aspartate
Evidence notes
Moderate evidence exists in clinical hepatology for ammonia reduction in hepatic encephalopathy. Very limited evidence in healthy individuals or athletic populations. Few rigorous RCTs in consumer health applications.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
Related in Amino Acid
Check a full stack
Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.
Open the checkerWhere does L-Ornithine L-Aspartate fit in your stack?
Answer two questions and get a stack graded on research — every ingredient scored on the evidence behind it, not the marketing.
Build my stack2 questions · free · no account needed to start
Also on iPhone — get the free app
Evidence-based supplement guides, no spam
We send a short digest when new guides drop — nothing else. No affiliate pushes, no sponsored content, unsubscribe anytime.
Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.