Skip to main content

Amino Acid

L-Ornithine L-Aspartate

Also known as: LOLA, ornithine aspartate, L-ornithine-L-aspartate salt

C
Evidence

L-Ornithine L-Aspartate is a combined amino acid supplement studied primarily for its potential role in ammonia metabolism and liver health support. Evidence exists mainly in clinical settings for hepatic encephalopathy management, with limited data in healthy populations.

Primary uses

  • Ammonia metabolism support
  • Liver health
  • Athletic recovery (limited evidence)
  • Hepatic encephalopathy management (clinical use)

How it works

  • Substrate for hepatic urea cycle enzymes to increase ammonia clearance
  • Supports nitrogen metabolism through ornithine and aspartate donation
  • May enhance muscle protein synthesis

Dosage

Typical range
2-3 grams daily, divided into 2-3 doses
Timing
With meals for better tolerance
With food
Recommended to reduce potential gastrointestinal discomfort
Duration
Clinical studies typically span 4-12 weeks; optimal duration for healthy populations unclear
Special populations
Not recommended for children without medical supervision; consult healthcare provider if pregnant or nursing

Forms

  • Powder· 70/100
  • Capsule· 70/100
  • Tablet· 70/100

Safety

Common side effects

  • Nausea
  • Gastrointestinal upset
  • Diarrhea (mild, dose-dependent)

Contraindications

  • Severe renal impairment
  • Known hypersensitivity to ornithine or aspartate

Evidence notes

Moderate evidence exists in clinical hepatology for ammonia reduction in hepatic encephalopathy. Very limited evidence in healthy individuals or athletic populations. Few rigorous RCTs in consumer health applications.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

Related in Amino Acid

Check a full stack

Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.

Open the checker

Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.