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Cruciferous

Indole-3-Carbinol (I3C)

Also known as: I3C, Indole-3-carbinol, Cruciferous extract

B
Evidence

Cruciferous compound that converts to DIM and supports estrogen metabolism.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Estrogen metabolism
  • Hormone balance
  • Detoxification

How it works

  • Converts to DIM in stomach
  • Modulates estrogen metabolism
  • From cruciferous vegetables
  • Supports healthy estrogen balance

Dosage

Typical range
200-400mg daily
Timing
With meals
With food
Yes
Duration
Ongoing for estrogen support
Special populations
Estrogen metabolism support

Forms

  • Capsules
  • With DIM

Safety

Common side effects

  • GI upset
  • Skin rash (rare)

Contraindications

  • Hormone-sensitive cancers (discuss)

Evidence notes

Precursor to DIM, supports estrogen metabolism

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.