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Joint/Skin

Hydrolyzed Collagen Type II

Also known as: Type II collagen peptides, hydrolyzed type II collagen, collagen II, UC-II (undenatured form)

B
Evidence

Hydrolyzed Type II collagen is a processed form of collagen derived primarily from chicken cartilage, broken down into smaller peptides for improved bioavailability. It is formulated to support joint cartilage integrity and resilience.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Joint health and cartilage support
  • Joint comfort and flexibility
  • Connective tissue maintenance

How it works

  • Provides bioavailable collagen peptides that accumulate in articular cartilage
  • May trigger immune tolerance to type II collagen, reducing cartilage-degrading immune responses
  • Supplies amino acids (glycine, proline, hydroxyproline) needed for collagen synthesis

Dosage

Typical range
1,000–3,000 mg daily (10 mg undenatured type II collagen per capsule in UC-II formulations; 1,500–2,000 mg hydrolyzed form more common)
Timing
Morning dosing with breakfast is standard; can be taken anytime
With food
May be taken with or without food; taking with vitamin C enhances collagen synthesis
Duration
Benefits typically appear after 8–12 weeks of consistent use; some studies show cumulative benefit up to 16+ weeks
Special populations
Safe in most populations; generally recognized as safe in pregnancy based on collagen safety data. Avoid if poultry allergy present. Consult provider if immunocompromised (some evidence suggests immune modulation).

Forms

  • Capsules· 70/100
  • Powder· 70/100
  • Tablets· 70/100

Safety

Common side effects

  • Mild digestive upset (rare)
  • Aftertaste or fishy flavor (powder form)

Contraindications

  • Poultry allergy or sensitivity (primary source)
  • Known shellfish allergy if processing environment involves cross-contamination

Evidence notes

Solid evidence from RCTs showing improvements in joint comfort and cartilage markers. Some evidence suggests oral tolerance induction (particularly for undenatured UC-II form). Effect sizes are moderate; benefits depend on consistent use and adequate duration.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.