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Joint/Skin

Hydrolyzed Collagen Type II

Also known as: Type II collagen peptides, hydrolyzed type II collagen, collagen II, UC-II (undenatured form)

B
Evidence

Hydrolyzed Type II collagen is a processed form of collagen derived primarily from chicken cartilage, broken down into smaller peptides for improved bioavailability. It is formulated to support joint cartilage integrity and resilience.

Primary uses

  • Joint health and cartilage support
  • Joint comfort and flexibility
  • Connective tissue maintenance

How it works

  • Provides bioavailable collagen peptides that accumulate in articular cartilage
  • May trigger immune tolerance to type II collagen, reducing cartilage-degrading immune responses
  • Supplies amino acids (glycine, proline, hydroxyproline) needed for collagen synthesis

Dosage

Typical range
1,000–3,000 mg daily (10 mg undenatured type II collagen per capsule in UC-II formulations; 1,500–2,000 mg hydrolyzed form more common)
Timing
Morning dosing with breakfast is standard; can be taken anytime
With food
May be taken with or without food; taking with vitamin C enhances collagen synthesis
Duration
Benefits typically appear after 8–12 weeks of consistent use; some studies show cumulative benefit up to 16+ weeks
Special populations
Safe in most populations; generally recognized as safe in pregnancy based on collagen safety data. Avoid if poultry allergy present. Consult provider if immunocompromised (some evidence suggests immune modulation).

Forms

  • Capsules· 70/100
  • Powder· 70/100
  • Tablets· 70/100

Safety

Common side effects

  • Mild digestive upset (rare)
  • Aftertaste or fishy flavor (powder form)

Contraindications

  • Poultry allergy or sensitivity (primary source)
  • Known shellfish allergy if processing environment involves cross-contamination

Evidence notes

Solid evidence from RCTs showing improvements in joint comfort and cartilage markers. Some evidence suggests oral tolerance induction (particularly for undenatured UC-II form). Effect sizes are moderate; benefits depend on consistent use and adequate duration.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.