Antioxidant

Epicatechin (90% (-)-Epicatechin from Camellia sinensis)

Also known as: (-)-Epicatechin, Green tea catechin extract, Camellia sinensis extract, ECg

Evidence

Epicatechin is a plant-derived polyphenol and flavanol found abundantly in green tea and cocoa, known for potent antioxidant and vascular effects. Research suggests it may support endothelial function, cardiovascular health, and exercise performance.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

Cardiovascular support
Endothelial function
Antioxidant protection
Exercise performance
Vascular health

How it works

Nitric oxide (NO) production and bioavailability
Antioxidant free radical scavenging
AMPK and mitochondrial biogenesis activation
Vascular endothelial growth factor (VEGF) signaling
Anti-inflammatory cytokine modulation

Dosage

Typical range: 100-300 mg daily
Timing: With meals for absorption; timing relative to exercise varies by study
With food: May be taken with or without food; may enhance absorption with fat or carbohydrates
Duration: Most studies assess 4-12 weeks; chronic supplementation appears safe
Special populations: Generally recognized as safe in pregnancy; no major age restrictions

Forms

Extract powder· 70/100
Standardized capsule· 70/100
Tablet· 70/100

Safety

Common side effects

Generally well-tolerated
Rare: mild GI upset at high doses

Contraindications

Avoid if allergic to tea/cocoa plants
Use cautiously with bleeding disorders (mild anticoagulant activity)

Evidence notes

Solid human and animal evidence for vascular and cardiovascular effects; multiple RCTs support NO-mediated improvements in blood flow and endothelial function; less robust evidence for cognitive enhancement alone, though used in neurostack formulations.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.