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Antioxidant

Epicatechin (90% (-)-Epicatechin from Camellia sinensis)

Also known as: (-)-Epicatechin, Green tea catechin extract, Camellia sinensis extract, ECg

B
Evidence

Epicatechin is a plant-derived polyphenol and flavanol found abundantly in green tea and cocoa, known for potent antioxidant and vascular effects. Research suggests it may support endothelial function, cardiovascular health, and exercise performance.

Primary uses

  • Cardiovascular support
  • Endothelial function
  • Antioxidant protection
  • Exercise performance
  • Vascular health

How it works

  • Nitric oxide (NO) production and bioavailability
  • Antioxidant free radical scavenging
  • AMPK and mitochondrial biogenesis activation
  • Vascular endothelial growth factor (VEGF) signaling
  • Anti-inflammatory cytokine modulation

Dosage

Typical range
100-300 mg daily
Timing
With meals for absorption; timing relative to exercise varies by study
With food
May be taken with or without food; may enhance absorption with fat or carbohydrates
Duration
Most studies assess 4-12 weeks; chronic supplementation appears safe
Special populations
Generally recognized as safe in pregnancy; no major age restrictions

Forms

  • Extract powder· 70/100
  • Standardized capsule· 70/100
  • Tablet· 70/100

Safety

Common side effects

  • Generally well-tolerated
  • Rare: mild GI upset at high doses

Contraindications

  • Avoid if allergic to tea/cocoa plants
  • Use cautiously with bleeding disorders (mild anticoagulant activity)

Evidence notes

Solid human and animal evidence for vascular and cardiovascular effects; multiple RCTs support NO-mediated improvements in blood flow and endothelial function; less robust evidence for cognitive enhancement alone, though used in neurostack formulations.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.