Primary Research · 1992

Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation

Harris, Söderlund, and Hultman · Clinical Science, 1992

Key finding

Landmark paper establishing that oral creatine supplementation raises muscle creatine concentration — founding the loading-phase protocol.

Read the paper

Open on PubMed

https://pubmed.ncbi.nlm.nih.gov/1327657/

Cited in 1 guide

Guide
Creatine Loading Phase: Evidence-Based Guide 2026
Find out if creatine loading is worth it. We break down the saturation science, compare both protocols, and tell you which fits your timeline.

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