Fat-soluble vitamins
Vitamin D
Bone · immune
Calcium absorption, bone mineralization, immune modulation.
Upper-limit caution
The Tolerable Upper Intake Level for Vitamin D is 100 mcg per day. Routine intakes above this level — counting food + supplements — raise the risk of adverse effects. Multivitamins, fortified foods, and standalone supplements stack faster than people expect.
What Vitamin D does
Vitamin D acts more like a hormone than a classical vitamin: 25(OH)D circulates and is converted to active 1,25(OH)₂D in the kidneys, which regulates calcium absorption, bone mineralization, and immune cell behavior. Most adults in temperate latitudes do not get enough from sun exposure year-round — winter sun above ~37°N is too oblique to drive cutaneous synthesis. Diet alone rarely covers the gap. Below 20 ng/mL serum 25(OH)D is the conventional deficiency cutoff; 30–60 ng/mL is the commonly targeted sufficient range.
Food sources of Vitamin D
Approximate Vitamin D content per serving. Whole-food intake counts toward your daily total alongside any supplemental dose.
| Food | Serving | Vitamin D |
|---|---|---|
| Wild salmon (cooked) | 3 oz | 15 mcg (600 IU) |
| Cod liver oil | 1 tsp | 11 mcg (450 IU) |
| Fortified milk | 1 cup | 3 mcg (120 IU) |
| Canned sardines (with bones) | 3 oz | 4 mcg (165 IU) |
| Egg yolk | 1 large | 1 mcg (45 IU) |
| UV-exposed mushrooms | 1 cup | 10 mcg (400 IU) |
Signs of Vitamin D deficiency
- ●Bone pain, muscle weakness, frequent falls in older adults
- ●Stress fractures or low bone density on DXA
- ●Fatigue and low mood that improves with repletion (mechanism debated, association common)
- ●Severe deficiency: rickets in children, osteomalacia in adults
Who needs more Vitamin D
Groups and situations where Vitamin D requirements rise or status commonly runs low:
- ●Living above ~37° latitude (Boston, Madrid, Beijing) from October through March
- ●Darker skin tones — melanin reduces UVB-driven synthesis 3–6×
- ●Indoor lifestyle, sunscreen-heavy use, full-coverage clothing
- ●Older adults — skin synthesis drops ~50% by age 70
- ●Obesity — D is sequestered in adipose tissue and less bioavailable
Forms to avoid
Not all Vitamin D forms absorb equally well. The following forms are commonly used because they're cheap, but their bioavailability is materially lower than alternatives — watch for them on supplement labels:
- d2
- ergocalciferol
Formulate's product scoring penalizes these forms when they appear as the primary Vitamin D source — see the methodology page for the rubric.
How Vitamin D appears on labels
Supplement labels list Vitamin D under several names depending on the chemical form used. Any of these on an ingredients panel counts toward your Vitamin D intake:
- vitamin d
- vitamin d3
- vitamin d2
- cholecalciferol
- ergocalciferol
Best supplements for Vitamin D
Top-scoring supplements in our catalog that list Vitamin D on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Deep dive
For mechanism of action, dosing protocols, evidence grade, and interaction warnings on Vitamin D, see the full encyclopedia entry:
Vitamin D encyclopedia entry →Conditions where Vitamin D has evidence
Vitamin D appears on the supplement list for the following condition pages — each links to the full evidence summary, dose, and lifestyle context.
Research on Vitamin D
Peer-reviewed studies in our research database that reference Vitamin D. Each entry links to a detailed methodology review.
- Neale et al., 2022 · The Lancet Diabetes & EndocrinologyThe D-Health Trial: a randomised controlled trial of the effect of vitamin D on mortality
- Manson et al., 2019 · New England Journal of MedicineVitamin D Supplements and Prevention of Cancer and Cardiovascular Disease
- Scragg et al., 2017 · JAMA CardiologyMonthly High-Dose Vitamin D Supplementation and Cardiovascular Disease (ViDA)
- Martineau AR, Jolliffe DA, Hooper RL, et al., 2017 · BMJ · Grade BVitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data
- Dawson-Hughes et al., 2015 · Journal of the Academy of Nutrition and DieteticsDietary fat increases vitamin D-3 absorption
Guides covering Vitamin D
Long-form articles in our guide library that go deeper on Vitamin D — comparisons, protocols, and reviews.
Frequently asked questions
What is the daily target for Vitamin D?
What foods are highest in Vitamin D?
What is the best form of Vitamin D to supplement?
What are the signs of Vitamin D deficiency?
Who is most at risk for low Vitamin D?
Related fat-soluble vitamins
Track your full intake
Formulate's free web app aggregates Vitamin D (and ~40 other nutrients) across every supplement in your stack — flagging underdoses, overlaps, and upper-limit overshoots in one view.
Track your intake free →Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Targets and upper limits are general adult reference values; individual needs vary by age, sex, pregnancy status, and clinical context.







