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Mineral

Zinc Orotate

Also known as: zinc orotic acid, orotic acid zinc, Zinc (as Zinc Orotate)

B
Evidence

Zinc orotate is a chelated form of zinc bound to orotic acid, intended to enhance absorption and bioavailability compared to standard zinc salts. While zinc itself has strong evidence for immune function and wound healing, evidence specific to the orotate form is limited.

Primary uses

  • Immune function support
  • Wound healing
  • Protein synthesis
  • Antioxidant defense
  • Cellular growth and reproduction

How it works

  • Cofactor for 300+ enzymes including DNA polymerase and superoxide dismutase
  • Supports T-cell mediated immunity
  • Enhances skin barrier and wound repair
  • The orotate carrier may improve intestinal absorption and cellular uptake

Dosage

Typical range
15–30 mg elemental zinc daily
Timing
Any time of day; consistent timing recommended
With food
With food to minimize gastrointestinal upset; avoid with high-fiber or high-phytate meals which may reduce absorption
Duration
Safe for long-term use; monitor intake from all sources to avoid exceeding 40 mg/day upper limit
Special populations
Adult RDA: 8 mg (women), 11 mg (men). Pregnant/lactating women require 11–12 mg daily. Avoid excessive supplementation in older adults without medical supervision.

Forms

  • Powder· 70/100
  • Capsule· 70/100
  • Tablet· 70/100

Safety

Common side effects

  • Nausea (especially on empty stomach)
  • Copper deficiency with chronic high-dose use (>50 mg/day)
  • Metallic taste
  • Headache (rare)

Contraindications

  • Do not exceed 40 mg/day long-term without medical monitoring
  • Caution in patients with copper deficiency history
  • Use cautiously with certain antibiotics or bisphosphonates

Evidence notes

Zinc itself has strong evidence (Grade A) for immune support and deficiency correction. The orotate chelate form lacks direct RCT evidence compared to other zinc forms, but the underlying mineral has robust clinical support. Grade lowered to B due to limited form-specific data.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.