Adaptogen
Salidroside
Also known as: salidroside, rhodioloside, tyrosol-xyloside, rheumatoxin
Salidroside is an active phenolic compound found in Rhodiola rosea that exhibits antioxidant and neuroprotective properties. Limited human evidence supports traditional use for stress adaptation and mental fatigue, though most research is conducted in vitro or in animal models.
Primary uses
- Stress management
- Mental fatigue
- Antioxidant support
- Neuroprotection
How it works
- Antioxidant activity via ROS scavenging
- Mitochondrial function support
- HIF-1α pathway modulation
- Potential monoamine modulation
Dosage
- Typical range
- 50-300 mg daily (as isolated compound or via Rhodiola extract)
- Timing
- Morning to early afternoon preferred for adaptogenic effect
- With food
- May be taken with or without food
- Duration
- Adaptogenic effects typically require 2-4 weeks of consistent use
- Special populations
- Limited safety data in pregnancy; caution in bipolar disorder due to potential mood effects
Safety
Common side effects
- Minimal reported; rare insomnia or restlessness at high doses
Contraindications
- Bipolar disorder (potential mood elevation)
- Pregnancy/lactation (insufficient data)
Evidence notes
Salidroside shows promise in cell and animal studies for neuroprotection and stress resilience, but human clinical data remains limited. Efficacy likely depends on Rhodiola rosea whole-plant synergy rather than isolated compound.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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