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Adaptogen

Salidroside

Also known as: salidroside, rhodioloside, tyrosol-xyloside, rheumatoxin

C
Evidence

Salidroside is an active phenolic compound found in Rhodiola rosea that exhibits antioxidant and neuroprotective properties. Limited human evidence supports traditional use for stress adaptation and mental fatigue, though most research is conducted in vitro or in animal models.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Stress management
  • Mental fatigue
  • Antioxidant support
  • Neuroprotection

How it works

  • Antioxidant activity via ROS scavenging
  • Mitochondrial function support
  • HIF-1α pathway modulation
  • Potential monoamine modulation

Dosage

Typical range
50-300 mg daily (as isolated compound or via Rhodiola extract)
Timing
Morning to early afternoon preferred for adaptogenic effect
With food
May be taken with or without food
Duration
Adaptogenic effects typically require 2-4 weeks of consistent use
Special populations
Limited safety data in pregnancy; caution in bipolar disorder due to potential mood effects

Safety

Common side effects

  • Minimal reported; rare insomnia or restlessness at high doses

Contraindications

  • Bipolar disorder (potential mood elevation)
  • Pregnancy/lactation (insufficient data)

Evidence notes

Salidroside shows promise in cell and animal studies for neuroprotection and stress resilience, but human clinical data remains limited. Efficacy likely depends on Rhodiola rosea whole-plant synergy rather than isolated compound.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.