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Enzyme

Pepsin (Aspergillus niger)

Also known as: fungal pepsin, microbial pepsin, Aspergillus niger pepsin, acid protease

C
Evidence

Pepsin is a proteolytic enzyme derived from Aspergillus niger fungus that breaks down proteins in acidic environments, primarily used in digestive support supplements. It is commonly paired with betaine HCl to support gastric protein digestion in individuals with low stomach acid.

Primary uses

  • Protein digestion support
  • Digestive enzyme replacement
  • Hypochlorhydria support (low stomach acid)

How it works

  • Proteolytic enzyme that cleaves peptide bonds in acidic pH (optimal pH 1.5-2.5)
  • Breaks down dietary proteins into smaller peptides for improved absorption

Dosage

Typical range
100-500 mg per dose
Timing
With meals, particularly protein-containing meals
With food
Must be taken with food; requires acidic gastric environment to be effective
Duration
May be used short-term or as ongoing digestive support; no established maximum duration
Special populations
Should not be used by individuals with peptic ulcer disease or severe gastritis without medical supervision

Forms

  • Capsule· 70/100
  • Tablet· 70/100

Safety

Common side effects

  • Generally well-tolerated
  • Rare: mild GI discomfort, nausea

Contraindications

  • Active peptic ulcer disease
  • Severe gastritis or esophagitis
  • Allergy to Aspergillus species

Evidence notes

Limited clinical evidence specific to Aspergillus niger-derived pepsin. General enzyme therapy shows modest evidence; fungal pepsin efficacy compared to animal-sourced pepsin is not well-established in RCTs. Most evidence is theoretical or from small studies.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.