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Amino Acid

N,N-Dimethylglycine HCl

Also known as: DMG HCl, Dimethylglycine hydrochloride, N,N-DMG, DMG

C
Evidence

N,N-Dimethylglycine (DMG) is a derivative of the amino acid glycine that functions as a methyl donor and may support methylation pathways and energy metabolism. Limited clinical evidence exists for most purported benefits, with most research conducted in small, dated studies or animal models.

Primary uses

  • Athletic performance and endurance
  • Immune function support
  • Methylation pathway support
  • Energy and oxygen utilization

How it works

  • Methyl donor in one-carbon metabolism
  • Potential improvement in oxygen utilization efficiency
  • Support for mitochondrial energy production

Dosage

Typical range
500–3000 mg daily
Timing
Divided doses, typically with meals
With food
May be taken with or without food
Duration
Typical supplementation periods in studies range from 4–8 weeks; long-term safety data limited
Special populations
Safety in pregnancy/lactation not established; use only under professional guidance in pediatric populations

Forms

  • Powder (HCl salt)· 70/100
  • Capsule· 70/100

Safety

Common side effects

  • Nausea
  • Diarrhea
  • Fishy body odor (from trimethylamine metabolism)

Contraindications

  • Pregnancy (insufficient safety data)
  • Choline deficiency or related metabolic disorders (may interact with methylation)
  • History of mental health disorders involving homocysteine metabolism (theoretical concern)

Evidence notes

Evidence is preliminary and limited. Some small, older studies suggest potential ergogenic effects in athletic populations, but modern high-quality RCTs are lacking. Most mechanistic claims are theoretically sound but lack robust human clinical validation.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.