Other

Mannitol

Also known as: D-mannitol, manna sugar, Osmitrol

Evidence

Mannitol is a sugar alcohol used primarily as an osmotic laxative and sweetening agent in supplements. It has minimal systemic absorption and is primarily used for gastrointestinal applications rather than performance or health enhancement.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

Osmotic laxative/digestive support
Sweetening agent in supplement formulations
Bulking agent

How it works

Osmotic effect in the digestive tract drawing water into the intestinal lumen
Non-digestible carbohydrate that resists colonic absorption

Dosage

Typical range: 5-20 grams daily
Timing: Can be taken once or divided into multiple doses; typically morning or as needed
With food: May be taken with or without food; effects are gastrointestinal
Duration: Safe for short-term or occasional use; long-term daily use should be monitored
Special populations: Use with caution in individuals with fructose intolerance or FODMAP sensitivity; contraindicated in bowel obstruction

Forms

Powder· 70/100
Tablet· 70/100
Capsule· 70/100

Safety

Common side effects

Bloating
Gas
Abdominal cramping
Diarrhea (dose-dependent)

Contraindications

Intestinal obstruction
Fructose intolerance
Severe renal impairment
Undiagnosed abdominal pain

Evidence notes

Mannitol is a well-established osmotic laxative with decades of clinical use and safety data. Evidence for efficacy as a digestive aid is good. Grade B reflects established clinical utility, though it is not typically researched for nootropic or performance benefits.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.