Hormone Modulator
DIM (Diindolylmethane)
Also known as: Diindolylmethane, 3,3'-Diindolylmethane
B
Evidence
Cruciferous vegetable compound that modulates estrogen metabolism, used by men and women.
Primary uses
- Estrogen metabolism
- Hormone balance
- May support testosterone ratio
How it works
- Modulates estrogen metabolism
- Shifts to beneficial 2-OH metabolites
- May reduce 16-OH and 4-OH estrogens
- Used by both men and women
Dosage
- Typical range
- 100-300mg daily
- Timing
- With meals
- With food
- Yes, fat helps absorption
- Duration
- Can use long-term
- Special populations
- Estrogen metabolism support, men on TRT, women's hormone balance
Forms
- Capsules with BioPerine
- Capsules standalone
Safety
Common side effects
- Headache
- GI upset
- Darker urine
- Hormonal adjustment
Contraindications
- Hormone-sensitive cancers (discuss with oncologist)
Evidence notes
Good evidence for estrogen metabolism modulation
Grade B: Some human trials support key claims; further confirmation needed.
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