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Hormone Modulator

DIM (Diindolylmethane)

Also known as: Diindolylmethane, 3,3'-Diindolylmethane

B
Evidence

Cruciferous vegetable compound that modulates estrogen metabolism, used by men and women.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Estrogen metabolism
  • Hormone balance
  • May support testosterone ratio

How it works

  • Modulates estrogen metabolism
  • Shifts to beneficial 2-OH metabolites
  • May reduce 16-OH and 4-OH estrogens
  • Used by both men and women

Dosage

Typical range
100-300mg daily
Timing
With meals
With food
Yes, fat helps absorption
Duration
Can use long-term
Special populations
Estrogen metabolism support, men on TRT, women's hormone balance

Forms

  • Capsules with BioPerine
  • Capsules standalone

Safety

Common side effects

  • Headache
  • GI upset
  • Darker urine
  • Hormonal adjustment

Contraindications

  • Hormone-sensitive cancers (discuss with oncologist)

Products containing DIM (Diindolylmethane)

Top-scoring supplements in our catalog that list DIM (Diindolylmethane) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Thorne
Hormone Advantage
90
See all products →

Evidence notes

Good evidence for estrogen metabolism modulation

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.