Hormone Modulator
DIM (Diindolylmethane)
Also known as: Diindolylmethane, 3,3'-Diindolylmethane
Cruciferous vegetable compound that modulates estrogen metabolism, used by men and women.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every DIM (Diindolylmethane) product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Nutricost DIM Capsules | 94 A | $0.17 |
| 2 | Thorne Hormone Advantage | 90 A | $0.85 |
| 3 | Pure Encapsulations DIMPRO 100 | 88 A | $0.98 |
| 4 | Pure Encapsulations UltraDetox 10-Day Pure Pack | 83 A- | $7.55 |
| 5 | Pure Encapsulations PureGenomics UltraMultivitamin | 82 A- | $1.75 |
| 6 | Integrative Therapeutics Indolplex | 82 A- | $1.68 |
| 7 | Pure Encapsulations DIM Detox | 80 A- | $1.93 |
| 8 | NOW Foods DIM 200 | 78 B+ | $0.22 |
| 9 | Nature's Way Estrobalance | 77 B+ | $1.08 |
| 10 | Vital Nutrients Hormone Balance | 77 B+ | $1.20 |
| 11 | Nature's Way Protective Breast Formula | 71 B | $2.95 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much DIM (Diindolylmethane) should I take?
The typical range is 100-300mg daily. Can use long-term
When should I take DIM (Diindolylmethane)?
With meals. Yes, fat helps absorption.
Which form of DIM (Diindolylmethane) is best?
Capsules with BioPerine — Enhanced absorption. Other forms in the catalog: Capsules standalone.
Is DIM (Diindolylmethane) safe?
Commonly reported: Headache, GI upset, Darker urine, Hormonal adjustment. Serious warnings: May affect hormone-sensitive conditions. May affect liver enzymes
Which DIM (Diindolylmethane) supplement scores highest?
Nutricost DIM Capsules, at 94/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Estrogen metabolism
- Hormone balance
- May support testosterone ratio
How it works
- Modulates estrogen metabolism
- Shifts to beneficial 2-OH metabolites
- May reduce 16-OH and 4-OH estrogens
- Used by both men and women
Dosage
- Typical range
- 100-300mg daily
- Timing
- With meals
- With food
- Yes, fat helps absorption
- Duration
- Can use long-term
- Special populations
- Estrogen metabolism support, men on TRT, women's hormone balance
Forms
- Capsules with BioPerine
- Capsules standalone
Safety
Common side effects
- Headache
- GI upset
- Darker urine
- Hormonal adjustment
Contraindications
- Hormone-sensitive cancers (discuss with oncologist)
Products containing DIM (Diindolylmethane)
Top-scoring supplements in our catalog that list DIM (Diindolylmethane) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Good evidence for estrogen metabolism modulation
Grade B: Some human trials support key claims; further confirmation needed.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.