Terpene
d-Limonene
Also known as: Limonene, Orange peel extract, Citrus terpene
Citrus-derived compound that may help GERD by coating the esophagus and promoting normal peristalsis.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every d-Limonene product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Life Extension CoQ10 with d-Limonene | 78 B+ | $0.40 |
| 2 | Integrative Therapeutics D-Limonene | 74 B+ | $4.05 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much d-Limonene should I take?
The typical range is 1000mg every other day for 20 days, then as needed. Initial course then as needed
When should I take d-Limonene?
Empty stomach. Empty stomach, typically morning.
Which form of d-Limonene is best?
Softgels — Concentrated oil. Other forms in the catalog: Orange peel extract.
Is d-Limonene safe?
Commonly reported: Citrus burps, GI upset. Serious warnings: Not well-studied long-term. Safe
Which d-Limonene supplement scores highest?
Life Extension CoQ10 with d-Limonene, at 78/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- GERD support
- Heartburn
- Esophageal coating
How it works
- Coats esophageal lining
- Promotes normal peristalsis
- May neutralize gastric acid
- Citrus-derived
Dosage
- Typical range
- 1000mg every other day for 20 days, then as needed
- Timing
- Empty stomach
- With food
- Empty stomach, typically morning
- Duration
- Initial course then as needed
- Special populations
- GERD, chronic heartburn
Forms
- Softgels
- Orange peel extract
Safety
Common side effects
- Citrus burps
- GI upset
Contraindications
- Citrus allergy
Products containing d-Limonene
Top-scoring supplements in our catalog that list d-Limonene on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Limited but promising research for GERD
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.