Terpene

d-Limonene

Also known as: Limonene, Orange peel extract, Citrus terpene

Evidence

Citrus-derived compound that may help GERD by coating the esophagus and promoting normal peristalsis.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

GERD support
Heartburn
Esophageal coating

How it works

Coats esophageal lining
Promotes normal peristalsis
May neutralize gastric acid
Citrus-derived

Dosage

Typical range: 1000mg every other day for 20 days, then as needed
Timing: Empty stomach
With food: Empty stomach, typically morning
Duration: Initial course then as needed
Special populations: GERD, chronic heartburn

Forms

Softgels
Orange peel extract

Safety

Common side effects

Citrus burps
GI upset

Contraindications

Citrus allergy

Evidence notes

Limited but promising research for GERD

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.