Mineral

Calcium Orotate

Also known as: Calcium orotate, Orotic acid calcium salt, Ca orotate

Evidence

Calcium orotate is a calcium salt of orotic acid, proposed to enhance calcium absorption and bioavailability compared to standard calcium forms. Limited human evidence exists specifically for this form; efficacy relies primarily on its calcium content and theoretical advantages of the orotate carrier.

Primary uses

Bone health support
Calcium supplementation
Cardiovascular health

How it works

Provides elemental calcium for bone mineralization and cellular function
Orotic acid may enhance mineral absorption and cellular energy metabolism

Dosage

Typical range: 500–1000 mg elemental calcium daily (divided doses preferred)
Timing: With meals to enhance absorption
With food: Recommended; food enhances calcium absorption
Duration: Long-term use appropriate for bone health maintenance; typical supplementation ongoing
Special populations: Pregnant and lactating women have higher requirements; elderly may benefit from divided dosing

Forms

Powder· 70/100
Capsule· 70/100
Tablet· 70/100

Safety

Common side effects

Constipation
Bloating
Nausea
Mild gastrointestinal upset

Contraindications

History of kidney stones or hypercalcemia
Severe renal impairment
Parathyroid disorders

Evidence notes

Calcium supplementation in general is well-established (Grade A), but calcium orotate specifically lacks robust human RCT data. The orotate carrier has theoretical benefits in animal models but minimal human clinical validation for superior absorption or outcomes versus standard calcium forms.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.