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Short-Chain Fatty Acid

Butyrate (Tributyrin/Sodium Butyrate)

Also known as: Tributyrin, Sodium butyrate, Cal-Mag butyrate

B
Evidence

Primary fuel for colonocytes, supporting colon health, barrier function, and reducing inflammation.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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The highest-scored Butyrate (Tributyrin/Sodium Butyrate) product in our catalog (80/100). Track dose and overlaps in the app.
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Common questions

How much Butyrate (Tributyrin/Sodium Butyrate) should I take?

The typical range is 300-600mg tributyrin or 600-1200mg butyrate salts 2-3x daily. Ongoing for gut health

When should I take Butyrate (Tributyrin/Sodium Butyrate)?

With meals. Yes.

Which form of Butyrate (Tributyrin/Sodium Butyrate) is best?

Tributyrin — Slow-release, better absorbed. Other forms in the catalog: Sodium butyrate, Cal-Mag butyrate.

Is Butyrate (Tributyrin/Sodium Butyrate) safe?

Commonly reported: Burping (smells), GI upset initially. Serious warnings: Unpleasant smell/taste with some forms. Safe

Which Butyrate (Tributyrin/Sodium Butyrate) supplement scores highest?

Pure Encapsulations SunButyrate - TG liquid, at 80/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.

Primary uses

  • Colon health
  • Gut barrier
  • IBD support
  • Microbiome metabolite

How it works

  • Primary fuel for colon cells
  • Supports tight junctions
  • Anti-inflammatory in gut
  • Normally made by gut bacteria

Dosage

Typical range
300-600mg tributyrin or 600-1200mg butyrate salts 2-3x daily
Timing
With meals
With food
Yes
Duration
Ongoing for gut health
Special populations
IBD, leaky gut, those with low fiber intake

Forms

  • Tributyrin
  • Sodium butyrate
  • Cal-Mag butyrate

Safety

Common side effects

  • Burping (smells)
  • GI upset initially

Contraindications

  • None significant

Products containing Butyrate (Tributyrin/Sodium Butyrate)

Top-scoring supplements in our catalog that list Butyrate (Tributyrin/Sodium Butyrate) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Pure Encapsulations
SunButyrate - TG liquid
Find on Amazon
80
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Evidence notes

Good mechanistic evidence, growing clinical research

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.