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Short-Chain Fatty Acid

Butyrate (Tributyrin/Sodium Butyrate)

Also known as: Tributyrin, Sodium butyrate, Cal-Mag butyrate

B
Evidence

Primary fuel for colonocytes, supporting colon health, barrier function, and reducing inflammation.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Colon health
  • Gut barrier
  • IBD support
  • Microbiome metabolite

How it works

  • Primary fuel for colon cells
  • Supports tight junctions
  • Anti-inflammatory in gut
  • Normally made by gut bacteria

Dosage

Typical range
300-600mg tributyrin or 600-1200mg butyrate salts 2-3x daily
Timing
With meals
With food
Yes
Duration
Ongoing for gut health
Special populations
IBD, leaky gut, those with low fiber intake

Forms

  • Tributyrin
  • Sodium butyrate
  • Cal-Mag butyrate

Safety

Common side effects

  • Burping (smells)
  • GI upset initially

Contraindications

  • None significant

Evidence notes

Good mechanistic evidence, growing clinical research

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.