Short-Chain Fatty Acid
Butyrate (Tributyrin/Sodium Butyrate)
Also known as: Tributyrin, Sodium butyrate, Cal-Mag butyrate
B
Evidence
Primary fuel for colonocytes, supporting colon health, barrier function, and reducing inflammation.
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Primary uses
- Colon health
- Gut barrier
- IBD support
- Microbiome metabolite
How it works
- Primary fuel for colon cells
- Supports tight junctions
- Anti-inflammatory in gut
- Normally made by gut bacteria
Dosage
- Typical range
- 300-600mg tributyrin or 600-1200mg butyrate salts 2-3x daily
- Timing
- With meals
- With food
- Yes
- Duration
- Ongoing for gut health
- Special populations
- IBD, leaky gut, those with low fiber intake
Forms
- Tributyrin
- Sodium butyrate
- Cal-Mag butyrate
Safety
Common side effects
- Burping (smells)
- GI upset initially
Contraindications
- None significant
Evidence notes
Good mechanistic evidence, growing clinical research
Grade B: Some human trials support key claims; further confirmation needed.
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