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Antioxidant

Zeaxanthin from Marigold Flower Extract

Also known as: Zeaxanthin, Tagetes erecta extract, Marigold zeaxanthin, Xanthophyll

B
Evidence

Zeaxanthin is a carotenoid antioxidant naturally found in marigold flowers, primarily studied for its potential role in supporting eye health and macular pigment density. Evidence supports its use alongside lutein for maintaining vision, particularly in protecting the macula from age-related damage.

Primary uses

  • Eye health and vision support
  • Macular pigment density
  • Age-related macular degeneration (AMD) risk reduction
  • Antioxidant protection

How it works

  • Accumulates in the macula and protects against blue light and oxidative stress
  • Acts as a carotenoid antioxidant, neutralizing free radicals
  • Supports macular pigment optical density for visual filtering

Dosage

Typical range
6-20 mg daily
Timing
With meals for optimal absorption
With food
Recommended—fat-soluble carotenoid requiring dietary fat for absorption
Duration
Long-term use (weeks to months) may be needed to build macular pigment
Special populations
Often combined with lutein in 1:2 to 1:1 ratios for synergistic eye protection

Forms

  • Powder (5% standardization typical)· 70/100
  • Capsule· 70/100
  • Tablet· 70/100

Safety

Common side effects

  • Generally well-tolerated
  • Carotenemia (harmless yellowing of skin) at very high doses

Contraindications

  • No major contraindications documented
  • Caution in smokers—some data suggest high carotenoid intake may increase lung cancer risk in this population

Evidence notes

Good evidence exists for zeaxanthin's role in eye health, particularly from the AREDS2 trial and observational studies showing association between dietary zeaxanthin intake and reduced AMD risk. Evidence is solid but less extensive than for lutein. Most benefits are observed when combined with lutein and other nutrients.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.