Anti-inflammatory

PEA (Palmitoylethanolamide)

Also known as: Levagen, PEA, PEA (lipid), Palmidrol

Evidence

Endogenous fatty acid amide with anti-inflammatory and neuroprotective effects. Different from phenylethylamine.

Primary uses

Pain
Neuroprotection
Inflammation
Immune modulation

How it works

PPARα activation
Mast cell modulation
Endocannabinoid support

Dosage

Typical range: 300-600 mg daily
Timing: Divided doses
With food: Optional
Duration: Safe long-term
Special populations: Chronic pain, neuropathy, inflammation

Forms

Micronized powder
Capsules

Safety

Common side effects

Minimal

Contraindications

None known

Evidence notes

Endogenous anti-inflammatory lipid

Grade B: Some human trials support key claims; further confirmation needed.

Check a full stack

Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.

Open the checker

Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.