Other
β-Nicotinamide Adenine Dinucleotide (NAD+)
Also known as: NAD+, NAD, Nicotinamide Adenine Dinucleotide, Beta-NAD
NAD+ is a coenzyme essential for cellular energy metabolism, mitochondrial function, and NAD+-dependent enzyme activity (sirtuins, PARPs). While NAD+ levels decline with age, oral supplementation has limited bioavailability; research on direct NAD+ supplementation in humans remains preliminary.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every β-Nicotinamide Adenine Dinucleotide (NAD+) product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Nutricost NAD+ | 82 A- | $0.55 |
| 2 | Double Wood NAD+ Supplement | 82 A- | $1.33 |
| 3 | Codeage Liposomal NAD+ Ultra Capsules | 78 B+ | $3.00 |
| 4 | Codeage Liposomal NADH | 75 B+ | $0.83 |
| 5 | Country Life Coenzyme B-Complex Advanced | 71 B | $0.89 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much β-Nicotinamide Adenine Dinucleotide (NAD+) should I take?
The typical range is 250-500 mg daily. Long-term safety data in humans is limited; most studies are short-term (4-12 weeks)
When should I take β-Nicotinamide Adenine Dinucleotide (NAD+)?
Typically taken with meals. May improve absorption; food does not significantly impair uptake.
Which form of β-Nicotinamide Adenine Dinucleotide (NAD+) is best?
Capsule. Other forms in the catalog: Powder, Tablet.
Is β-Nicotinamide Adenine Dinucleotide (NAD+) safe?
Commonly reported: Mild nausea, Flushing (more common with high-dose niacin; less likely with NAD+ itself), Headache (rare).
Which β-Nicotinamide Adenine Dinucleotide (NAD+) supplement scores highest?
Nutricost NAD+, at 82/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Cellular energy production
- Mitochondrial function support
- Age-related NAD+ decline
- Sirtuin activation
How it works
- Serves as electron acceptor in glycolysis, citric acid cycle, and electron transport chain
- Substrate for NAD+-dependent enzymes (sirtuins, PARP, CD38)
- Supports ATP production and redox balance
Dosage
- Typical range
- 250-500 mg daily
- Timing
- Typically taken with meals
- With food
- May improve absorption; food does not significantly impair uptake
- Duration
- Long-term safety data in humans is limited; most studies are short-term (4-12 weeks)
- Special populations
- Safety in pregnancy, lactation, and children not established; use with caution in liver or kidney disease
Forms
- Capsule· 70/100
- Powder· 70/100
- Tablet· 70/100
Safety
Common side effects
- Mild nausea
- Flushing (more common with high-dose niacin; less likely with NAD+ itself)
- Headache (rare)
Contraindications
- Active gout or hyperuricemia (theoretical risk from purine metabolism)
- Severe liver disease
- Uncontrolled hypertension
Products containing β-Nicotinamide Adenine Dinucleotide (NAD+)
Top-scoring supplements in our catalog that list β-Nicotinamide Adenine Dinucleotide (NAD+) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Strong mechanistic rationale and animal data support NAD+ biology, but human RCT evidence for oral NAD+ supplementation is limited and inconsistent. Bioavailability concerns exist due to molecular size and intestinal degradation. Preclinical evidence is robust; clinical translation remains preliminary.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
β-Nicotinamide Adenine Dinucleotide (NAD+) compared head-to-head
Related in Other
Check a full stack
Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.
Open the checkerWhere does β-Nicotinamide Adenine Dinucleotide (NAD+) fit in your stack?
Answer two questions and get a stack graded on research — every ingredient scored on the evidence behind it, not the marketing.
Build my stack2 questions · free · no account needed to start
Also on iPhone — get the free app
Evidence-based supplement guides, no spam
We send a short digest when new guides drop — nothing else. No affiliate pushes, no sponsored content, unsubscribe anytime.
Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.