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Hoodia Gordonii Extract

Also known as: Hoodia Extract, Hoodia gordonii, Xhoba, Hoodia fleshy leaf

C
Evidence

Hoodia gordonii is a succulent plant traditionally used by San hunter-gatherers to suppress appetite, with preliminary studies suggesting potential appetite-suppressing effects through P57 alkaloid compounds. However, human clinical evidence remains limited and conflicting, with most marketed products lacking adequate standardization.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Appetite suppression
  • Weight management support
  • Hunger reduction

How it works

  • P57 alkaloid may signal satiety to the hypothalamus
  • Potential glucose metabolism modulation

Dosage

Typical range
400–1,000 mg daily
Timing
Typically taken 30–60 minutes before meals
With food
May be taken with or without food; some protocols suggest before meals for appetite suppression
Duration
Most studies used 12–16 weeks; long-term safety data limited
Special populations
Not recommended in pregnancy/lactation; limited safety data in children

Forms

  • Powder extract· 70/100
  • Capsules· 70/100
  • Tablets· 70/100

Safety

Common side effects

  • Nausea
  • Dizziness
  • Headache
  • Mild gastrointestinal upset

Contraindications

  • Pregnancy and lactation
  • Diabetes (may affect glucose levels)
  • Concurrent use of appetite suppressants or stimulants

Evidence notes

While some animal and small human studies suggest appetite-suppressing activity, the evidence base is limited and inconsistent. Few well-controlled RCTs in humans; many commercial products lack verified P57 content or standardization. Grade C reflects preliminary but not robust clinical support.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.