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Hoodia Gordonii Extract
Also known as: Hoodia Extract, Hoodia gordonii, Xhoba, Hoodia fleshy leaf
Hoodia gordonii is a succulent plant traditionally used by San hunter-gatherers to suppress appetite, with preliminary studies suggesting potential appetite-suppressing effects through P57 alkaloid compounds. However, human clinical evidence remains limited and conflicting, with most marketed products lacking adequate standardization.
Primary uses
- Appetite suppression
- Weight management support
- Hunger reduction
How it works
- P57 alkaloid may signal satiety to the hypothalamus
- Potential glucose metabolism modulation
Dosage
- Typical range
- 400–1,000 mg daily
- Timing
- Typically taken 30–60 minutes before meals
- With food
- May be taken with or without food; some protocols suggest before meals for appetite suppression
- Duration
- Most studies used 12–16 weeks; long-term safety data limited
- Special populations
- Not recommended in pregnancy/lactation; limited safety data in children
Forms
- Powder extract· 70/100
- Capsules· 70/100
- Tablets· 70/100
Safety
Common side effects
- Nausea
- Dizziness
- Headache
- Mild gastrointestinal upset
Contraindications
- Pregnancy and lactation
- Diabetes (may affect glucose levels)
- Concurrent use of appetite suppressants or stimulants
Evidence notes
While some animal and small human studies suggest appetite-suppressing activity, the evidence base is limited and inconsistent. Few well-controlled RCTs in humans; many commercial products lack verified P57 content or standardization. Grade C reflects preliminary but not robust clinical support.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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