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Phytonutrient

DIM (Diindolylmethane)

Also known as: Cruciferous compound, Cruciferous extract, DIM, Diindolylmethane

B
Evidence

Cruciferous compound that supports healthy estrogen metabolism and liver detoxification of hormones.

Primary uses

  • Estrogen metabolism
  • Hormone detox
  • Hormonal balance
  • Cancer prevention

How it works

  • Shifts estrogen to favorable metabolites (2-OH)
  • Supports liver hormone clearance
  • May have anti-cancer effects
  • Derived from I3C in cruciferous vegetables

Dosage

Typical range
100-200mg enhanced DIM daily
Timing
With meals
With food
Yes, enhances absorption
Duration
Long-term use appropriate
Special populations
Those with estrogen dominance, hormonal concerns, men on TRT

Forms

  • DIM with absorption enhancement
  • DIM plain
  • With BioPerine

Safety

Common side effects

  • GI upset
  • Headache
  • Darkened urine

Contraindications

  • Hormone-sensitive cancers (consult oncologist)

Evidence notes

Good evidence for estrogen metabolite ratios

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.