Herbal Extract
Astragalus membranaceus Extract (Cycloastragenol 10%)
Also known as: Cycloastragenol, Astragalus root extract, Astragaloside IV, Huang qi extract
Cycloastragenol is a triterpene compound derived from Astragalus membranaceus root that has been studied for potential telomerase activation and longevity support. Evidence remains preliminary with limited human clinical trials.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Astragalus membranaceus Extract (Cycloastragenol 10%) product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Nutricost Astragalus Capsules | 88 A | $0.07 |
| 2 | Pure Encapsulations PureCell | 87 A | $1.28 |
| 3 | Pure Encapsulations Phyto-ADR | 86 A- | $0.53 |
| 4 | Pure Encapsulations Th2 Modulator | 84 A- | $1.02 |
| 5 | NOW Foods Mushroom Immune Renew | 84 A- | $0.13 |
| 6 | Vital Nutrients Astragalus Root Extract 300mg | 82 A- | $0.64 |
| 7 | Nature's Way Astragalus | 80 A- | $0.44 |
| 8 | Bluebonnet Nutrition ASTRAGALUS ROOT EXTRACT | 80 A- | $0.42 |
| 9 | Codeage Clearhead Echinacea+ | 76 B+ | $1.10 |
| 10 | Bluebonnet Nutrition WELLNESS SUPPORT | 76 B+ | $1.33 |
| 11 | Vital Nutrients ViraCon | 76 B+ | $1.32 |
| 12 | Bluebonnet Nutrition LIQUID MULTI FORMULA TROPICAL FRUIT FLAVOR | 74 B+ | $1.40 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Astragalus membranaceus Extract (Cycloastragenol 10%) should I take?
The typical range is 10-50 mg cycloastragenol content daily (varies by product concentration). Long-term safety data in humans is limited; studies typically range 8-12 weeks
When should I take Astragalus membranaceus Extract (Cycloastragenol 10%)?
With or without food; morning or evening. Not critical; may be taken with meals for GI comfort.
Which form of Astragalus membranaceus Extract (Cycloastragenol 10%) is best?
Standardized extract capsule. Other forms in the catalog: 10% cycloastragenol concentration.
Is Astragalus membranaceus Extract (Cycloastragenol 10%) safe?
Commonly reported: Generally well-tolerated, Rare: mild GI upset, nausea.
Which Astragalus membranaceus Extract (Cycloastragenol 10%) supplement scores highest?
Nutricost Astragalus Capsules, at 88/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Cellular aging and longevity support
- Immune function support
- Telomerase activity
How it works
- Proposed telomerase activator (may support telomere length maintenance)
- Immunomodulatory effects
- Antioxidant and anti-inflammatory pathways
Dosage
- Typical range
- 10-50 mg cycloastragenol content daily (varies by product concentration)
- Timing
- With or without food; morning or evening
- With food
- Not critical; may be taken with meals for GI comfort
- Duration
- Long-term safety data in humans is limited; studies typically range 8-12 weeks
- Special populations
- Avoid during pregnancy/lactation; limited safety data in children
Forms
- Standardized extract capsule· 70/100
- 10% cycloastragenol concentration· 70/100
Safety
Common side effects
- Generally well-tolerated
- Rare: mild GI upset, nausea
Contraindications
- Autoimmune disease (immunostimulant potential)
- Pregnancy and lactation (insufficient safety data)
- Organ transplant recipients (may interfere with immunosuppression)
Products containing Astragalus membranaceus Extract (Cycloastragenol 10%)
Top-scoring supplements in our catalog that list Astragalus membranaceus Extract (Cycloastragenol 10%) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Most evidence is from in vitro and animal studies. Human clinical trials on cycloastragenol specifically are very limited. Traditional use of Astragalus is well-documented, but isolated cycloastragenol data in humans is insufficient for higher grading.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.