Herbal Extract
Astragalus membranaceus Extract (Cycloastragenol 10%)
Also known as: Cycloastragenol, Astragalus root extract, Astragaloside IV, Huang qi extract
Cycloastragenol is a triterpene compound derived from Astragalus membranaceus root that has been studied for potential telomerase activation and longevity support. Evidence remains preliminary with limited human clinical trials.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Cellular aging and longevity support
- Immune function support
- Telomerase activity
How it works
- Proposed telomerase activator (may support telomere length maintenance)
- Immunomodulatory effects
- Antioxidant and anti-inflammatory pathways
Dosage
- Typical range
- 10-50 mg cycloastragenol content daily (varies by product concentration)
- Timing
- With or without food; morning or evening
- With food
- Not critical; may be taken with meals for GI comfort
- Duration
- Long-term safety data in humans is limited; studies typically range 8-12 weeks
- Special populations
- Avoid during pregnancy/lactation; limited safety data in children
Forms
- Standardized extract capsule· 70/100
- 10% cycloastragenol concentration· 70/100
Safety
Common side effects
- Generally well-tolerated
- Rare: mild GI upset, nausea
Contraindications
- Autoimmune disease (immunostimulant potential)
- Pregnancy and lactation (insufficient safety data)
- Organ transplant recipients (may interfere with immunosuppression)
Evidence notes
Most evidence is from in vitro and animal studies. Human clinical trials on cycloastragenol specifically are very limited. Traditional use of Astragalus is well-documented, but isolated cycloastragenol data in humans is insufficient for higher grading.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.