Joint/Skin
Hyaluronic Acid
Also known as: Sodium Hyaluronate, Hyaluronate, HA, Hyaluronan (skin)
A naturally occurring polysaccharide that holds up to 1000x its weight in water, supporting skin hydration, joint lubrication, and connective tissue health. Sodium hyaluronate is the salt form with enhanced bioavailability.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Skin hydration
- Wrinkles
- Skin plumpness
- Anti-aging
- Skin hydration and elasticity
- Joint lubrication and comfort
- Connective tissue support
- Eye health (in topical/oral forms)
How it works
- Water-binding capacity for tissue hydration
- Structural component of extracellular matrix
- Joint synovial fluid support
- Cell proliferation signaling
Dosage
- Typical range
- 20-200 mg daily (oral); molecular weight varies by product
- Timing
- Consistent daily intake recommended
- With food
- Can be taken with or without food
- Duration
- Benefits accumulate over 4-8 weeks; typically requires ongoing use for sustained effects
- Special populations
- Safe for most; vegans may prefer non-animal sourced forms (some derived from rooster combs or bacterial fermentation)
Forms
- Low molecular weight
- High molecular weight
- Sodium hyaluronate (enhanced oral bioavailability)· 70/100
- Hyaluronic acid (higher molecular weight)· 70/100
- Low-molecular-weight hyaluronate (better absorption)· 70/100
Safety
Common side effects
- Generally well-tolerated
- Rare: mild gastrointestinal upset
Contraindications
- None known at supplemental doses
Products containing Hyaluronic Acid
Top-scoring supplements in our catalog that list Hyaluronic Acid on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
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Evidence notes
Good evidence from multiple RCTs for skin hydration and joint comfort; well-established physiological role. Oral bioavailability improved with low molecular weight forms and sodium salt.
Grade B: Some human trials support key claims; further confirmation needed.
Related in Joint/Skin
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.